SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB04723

Signal sequence   MLKKIVTALGMSGMLLASSNAIA

Length  23

Organism  Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)

UniProt ID  Q5NGV7,

Motif  1..23



Activity Information


Pathway  Sec

Natural/Artificial  Natural

Subcellular location  Periplasmic space

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB04723.cif

Structure  SPKB04723.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2320.89274

Aliphatic index  131.7391304

Isoelectric point  10.80537956

Charge (pH=7)   1.997394232

Topological polar surface area  879.57

Aromaticity  0

Average rotatable bonds  3.52173913

Number of hydrogen bond donors  31

Number of hydrogen bond acceptors  34

X logP energy  -7.9107

Hydropathy 



Literature Information


Title  Identification, recombinant expression, immunolocalization in macrophages, and T-cell responsiveness of the major extracellular proteins of Francisella tularensis.

DOI  10.1128/IAI.00257-06,

Publication Year  2006

PubMed ID  16790773,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.