SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB04688

Signal sequence   MKTLLLTLVVVTIVCLDLGYT

Length  21

Organism  Oxyuranus scutellatus scutellatus (Australian taipan) (Coastal taipan)

UniProt ID  Q45Z11,

Motif  1..21



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB04688.cif

Structure  SPKB04688.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2308.90384

Aliphatic index  185.2380952

Isoelectric point  6.157533513

Charge (pH=7)   -0.06468938

Topological polar surface area  809.79

Aromaticity  0.047619048

Average rotatable bonds  3.571428571

Number of hydrogen bond donors  30

Number of hydrogen bond acceptors  31

X logP energy  -2.5695

Hydropathy 



Literature Information


Title  Two novel alpha-neurotoxins isolated from the taipan snake, Oxyuranus scutellatus, exhibit reduced affinity for nicotinic acetylcholine receptors in brain and skeletal muscle.

DOI  10.1021/bi9600761,

Publication Year  1996

PubMed ID  8672493,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.