SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB04662

Signal sequence   MFALFLCIALASA

Length  13

Organism  Entamoeba histolytica (strain ATCC 30459 / HM-1:IMSS / ABRM)

UniProt ID  Q27650,

Motif  1..13



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB04662.cif

Structure  SPKB04662.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  1370.73084

Aliphatic index  150.7692308

Isoelectric point  5.922539791

Charge (pH=7)   -0.063990417

Topological polar surface area  432.75

Aromaticity  0.153846154

Average rotatable bonds  3.230769231

Number of hydrogen bond donors  16

Number of hydrogen bond acceptors  17

X logP energy  -0.3595

Hydropathy 



Literature Information


Title  Purification and molecular cloning of a major antibacterial protein of the protozoan parasite Entamoeba histolytica with lysozyme-like properties.

DOI  10.1111/j.1432-1033.1995.0831d.x,

Publication Year  1995

PubMed ID  7649184,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.