SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB04620

Signal sequence   MNFSIKSVIFLAIVALATLVSA

Length  22

Organism  Orpinomyces sp. (strain PC-2)

UniProt ID  Q01490,

Motif  1..22



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB04620.cif

Structure  SPKB04620.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2308.84804

Aliphatic index  164.0909091

Isoelectric point  9.700002532

Charge (pH=7)   0.997689266

Topological polar surface area  824.45

Aromaticity  0.090909091

Average rotatable bonds  3.409090909

Number of hydrogen bond donors  29

Number of hydrogen bond acceptors  30

X logP energy  -4.4961

Hydropathy 



Literature Information


Title  A cyclophilin from the polycentric anaerobic rumen fungus Orpinomyces sp. strain PC-2 is highly homologous to vertebrate cyclophilin B.

DOI  10.1073/pnas.92.7.2587,

Publication Year  1995

PubMed ID  7708690,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.