SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB04584

Signal sequence   MKTLLLTLVVMTIVCLDLGYT

Length  21

Organism  Ophiophagus hannah (King cobra) (Naja hannah)

UniProt ID  P82662,

Motif  1..21



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB04584.cif

Structure  SPKB04584.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2340.96384

Aliphatic index  171.4285714

Isoelectric point  6.157533513

Charge (pH=7)   -0.06468938

Topological polar surface area  809.79

Aromaticity  0.047619048

Average rotatable bonds  3.666666667

Number of hydrogen bond donors  30

Number of hydrogen bond acceptors  32

X logP energy  -2.4724

Hydropathy 



Literature Information


Title  Cloning and purification of alpha-neurotoxins from king cobra (Ophiophagus hannah).

DOI  10.1016/j.toxicon.2004.06.003,

Publication Year  2004

PubMed ID  15302536,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.