SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB04581

Signal sequence   MNFTKLFLLIAMAVLLLTGQSEA

Length  23

Organism  Aedes aegypti (Yellowfever mosquito) (Culex aegypti)

UniProt ID  P82592,

Motif  1..23



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB04581.cif

Structure  SPKB04581.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2525.10284

Aliphatic index  144.3478261

Isoelectric point  6.408795646

Charge (pH=7)   -0.000535612

Topological polar surface area  913.71

Aromaticity  0.086956522

Average rotatable bonds  3.695652174

Number of hydrogen bond donors  31

Number of hydrogen bond acceptors  33

X logP energy  -4.3861

Hydropathy 



Literature Information


Title  Antimicrobial activity spectrum, cDNA cloning, and mRNA expression of a newly isolated member of the cecropin family from the mosquito vector Aedes aegypti.

DOI  10.1074/jbc.274.29.20092,

Publication Year  1999

PubMed ID  10400619,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.