SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB04580

Signal sequence   MNRTRLFACLLLAVLILVHESNA

Length  23

Organism  Acanthoscurria gomesiana (Tarantula spider) (Phormictopus pheopygus)

UniProt ID  P82358,

Motif  1..23



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB04580.cif

Structure  SPKB04580.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2598.16314

Aliphatic index  156.9565217

Isoelectric point  8.55741055

Charge (pH=7)   1.028687175

Topological polar surface area  1019.94

Aromaticity  0.043478261

Average rotatable bonds  3.739130435

Number of hydrogen bond donors  37

Number of hydrogen bond acceptors  34

X logP energy  -6.83506

Hydropathy 



Literature Information


Title  Isolation and characterization of gomesin, an 18-residue cysteine-rich defense peptide from the spider Acanthoscurria gomesiana hemocytes with sequence similarities to horseshoe crab antimicrobial peptides of the tachyplesin family.

DOI  10.1074/jbc.M001491200,

Publication Year  2000

PubMed ID  10942757,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.