SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB04576

Signal sequence   MKWMVVALVCLQLLEA

Length  16

Organism  Suncus murinus (Asian house shrew) (Musk shrew)

UniProt ID  P81498,

Motif  1..16



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB04576.cif

Structure  SPKB04576.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  1847.36574

Aliphatic index  164.375

Isoelectric point  6.231833229

Charge (pH=7)   -0.062510328

Topological polar surface area  622.02

Aromaticity  0.0625

Average rotatable bonds  3.8125

Number of hydrogen bond donors  22

Number of hydrogen bond acceptors  23

X logP energy  0.2818

Hydropathy 



Literature Information


Title  Pepsinogens and pepsins from house musk shrew, Suncus murinus: purification, characterization, determination of the amino-acid sequences of the activation segments, and analysis of proteolytic specificities.

DOI  10.1093/oxfordjournals.jbchem.a021687,

Publication Year  1997

PubMed ID  9354369,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.