SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB04489

Signal sequence   MELSVAMYGLLCLLFSQAVP

Length  20

Organism  Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)

UniProt ID  P37240,

Motif  1..20



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB04489.cif

Structure  SPKB04489.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2185.68284

Aliphatic index  136.5

Isoelectric point  3.84996161

Charge (pH=7)   -1.063065708

Topological polar surface area  748.51

Aromaticity  0.1

Average rotatable bonds  3.45

Number of hydrogen bond donors  26

Number of hydrogen bond acceptors  29

X logP energy  -2.9287

Hydropathy 



Literature Information


Title  cDNA cloning of the beta subunit of teleost thyrotropin.

DOI  10.1073/pnas.90.13.6052,

Publication Year  1993

PubMed ID  8327483,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.