SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB04481

Signal sequence   MTWDGLPTQPLLMLLMLLFAAGSES

Length  25

Organism  Rattus norvegicus (Rat)

UniProt ID  P35572,

Motif  1..25



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB04481.cif

Structure  SPKB04481.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2736.29484

Aliphatic index  117.2

Isoelectric point  3.550073557

Charge (pH=7)   -1.999794094

Topological polar surface area  958.54

Aromaticity  0.08

Average rotatable bonds  3.44

Number of hydrogen bond donors  32

Number of hydrogen bond acceptors  36

X logP energy  -4.7516

Hydropathy 



Literature Information


Title  Identification of five different insulin-like growth factor binding proteins (IGFBPs) from adult rat serum and molecular cloning of a novel IGFBP-5 in rat and human.

DOI  NA,

Publication Year  1991

PubMed ID  1709938,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.