SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB04430

Signal sequence   MKTFLLLLLVLLELGQAPG

Length  19

Organism  Cavia porcellus (Guinea pig)

UniProt ID  P25796,

Motif  1..19



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB04430.cif

Structure  SPKB04430.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2069.61694

Aliphatic index  184.7368421

Isoelectric point  6.408795646

Charge (pH=7)   -0.000535612

Topological polar surface area  704.97

Aromaticity  0.052631579

Average rotatable bonds  3.631578947

Number of hydrogen bond donors  23

Number of hydrogen bond acceptors  25

X logP energy  -0.4257

Hydropathy 



Literature Information


Title  Gastric procathepsin E and progastricsin from guinea pig. Purification, molecular cloning of cDNAs, and characterization of enzymatic properties, with special reference to procathepsin E.

DOI  NA,

Publication Year  1992

PubMed ID  1644829,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.