SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB04417

Signal sequence   MKLLLLNILLLCCLA

Length  15

Organism  Entamoeba histolytica (strain ATCC 30459 / HM-1:IMSS / ABRM)

UniProt ID  P23502,

Motif  1..15



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB04417.cif

Structure  SPKB04417.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  1687.27674

Aliphatic index  240.6666667

Isoelectric point  8.229691165

Charge (pH=7)   0.873739834

Topological polar surface area  539.83

Aromaticity  0

Average rotatable bonds  3.866666667

Number of hydrogen bond donors  20

Number of hydrogen bond acceptors  21

X logP energy  1.2374

Hydropathy 



Literature Information


Title  Primary structure of the 170-kDa surface lectin of pathogenic Entamoeba histolytica.

DOI  10.1073/pnas.88.5.1849,

Publication Year  1991

PubMed ID  2000392,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.