SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB04325

Signal sequence   MQPRLGGPALLLLPPLLLLLLLGAGGGDCGARA

Length  33

Organism  Bos taurus (Bovine)

UniProt ID  P13384,

Motif  1..33



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB04325.cif

Structure  SPKB04325.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  3237.99904

Aliphatic index  153.9393939

Isoelectric point  8.54983383

Charge (pH=7)   0.936449445

Topological polar surface area  1163.55

Aromaticity  0

Average rotatable bonds  3.090909091

Number of hydrogen bond donors  39

Number of hydrogen bond acceptors  40

X logP energy  -7.06106

Hydropathy 



Literature Information


Title  The bovine insulin-like growth factor (IGF) binding protein purified from conditioned medium requires the N-terminal tripeptide in IGF-1 for binding.

DOI  10.1016/0006-291x(88)90580-3,

Publication Year  1988

PubMed ID  2450535,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.