SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB04315

Signal sequence   MALWMQCLPLVLVLFFSTPNTEA

Length  23

Organism  Xenopus laevis (African clawed frog)

UniProt ID  P12706,

Motif  1..23



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB04315.cif

Structure  SPKB04315.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2625.19724

Aliphatic index  118.6956522

Isoelectric point  3.849962145

Charge (pH=7)   -1.062215294

Topological polar surface area  885.9

Aromaticity  0.130434783

Average rotatable bonds  3.434782609

Number of hydrogen bond donors  30

Number of hydrogen bond acceptors  33

X logP energy  -2.9364

Hydropathy 



Literature Information


Title  Isolation and characterization of two different insulins from an amphibian, Xenopus laevis.

DOI  10.1210/endo-125-1-469,

Publication Year  1989

PubMed ID  2661211,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.