SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB04289

Signal sequence   MKLIKTFLFLFVVLLVLSEVSAEP

Length  24

Organism  Doratifera vulnerans (Mottled cup moth)

UniProt ID  P0DUS6,

Motif  1..24



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB04289.cif

Structure  SPKB04289.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2737.42004

Aliphatic index  166.25

Isoelectric point  6.530759447

Charge (pH=7)   0.000944477

Topological polar surface area  911.16

Aromaticity  0.125

Average rotatable bonds  3.75

Number of hydrogen bond donors  31

Number of hydrogen bond acceptors  33

X logP energy  -0.1443

Hydropathy 



Literature Information


Title  Production, composition, and mode of action of the painful defensive venom produced by a limacodid caterpillar, Doratifera vulnerans.

DOI  10.1073/pnas.2023815118,

Publication Year  2021

PubMed ID  33893140,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.