SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB04282

Signal sequence   MKVFFAVLIALFVCSMVIGIHG

Length  22

Organism  Buthus israelis (Israeli scorpion) (Buthus occitanus israelis)

UniProt ID  P0C908,

Motif  1..22



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB04282.cif

Structure  SPKB04282.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2396.05124

Aliphatic index  150.4545455

Isoelectric point  8.552755748

Charge (pH=7)   1.026623641

Topological polar surface area  749.35

Aromaticity  0.136363636

Average rotatable bonds  3.5

Number of hydrogen bond donors  27

Number of hydrogen bond acceptors  29

X logP energy  -0.0126

Hydropathy 



Literature Information


Title  Isolation of the first toxin from the scorpion Buthus occitanus israelis showing preference for Shaker potassium channels.

DOI  10.1016/j.febslet.2007.04.065,

Publication Year  2007

PubMed ID  17490656,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.