SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB04281

Signal sequence   MRALLARLLLCVLVVSDSKG

Length  20

Organism  Rhipicephalus sanguineus (Brown dog tick) (Ixodes sanguineus)

UniProt ID  P0C8E8,

Motif  1..20



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB04281.cif

Structure  SPKB04281.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2157.70444

Aliphatic index  170.5

Isoelectric point  9.828249571

Charge (pH=7)   1.936154411

Topological polar surface area  843.8

Aromaticity  0

Average rotatable bonds  3.7

Number of hydrogen bond donors  32

Number of hydrogen bond acceptors  29

X logP energy  -5.67696

Hydropathy 



Literature Information


Title  Ticks produce highly selective chemokine binding proteins with antiinflammatory activity.

DOI  10.1084/jem.20072689,

Publication Year  2008

PubMed ID  18678732,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.