SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB04187

Signal sequence   MEFWLSWVFLVAISKGVQC

Length  19

Organism  Homo sapiens (Human)

UniProt ID  P01767,

Motif  1..19



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB04187.cif

Structure  SPKB04187.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2243.70964

Aliphatic index  112.6315789

Isoelectric point  6.231833229

Charge (pH=7)   -0.062510328

Topological polar surface area  765.57

Aromaticity  0.210526316

Average rotatable bonds  3.684210526

Number of hydrogen bond donors  28

Number of hydrogen bond acceptors  27

X logP energy  -1.2575

Hydropathy 



Literature Information


Title  Complete amino acid sequence of the alpha 2 heavy chain of a human IgA2 immunoglobulin of the A2m (2) allotype.

DOI  10.1073/pnas.75.2.966,

Publication Year  1978

PubMed ID  416441,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.