SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB04186

Signal sequence   MELGLCWVFLVAILEGVQC

Length  19

Organism  Homo sapiens (Human)

UniProt ID  P01763,

Motif  1..19



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB04186.cif

Structure  SPKB04186.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2123.61434

Aliphatic index  153.6842105

Isoelectric point  3.61367315

Charge (pH=7)   -2.122414887

Topological polar surface area  720.6

Aromaticity  0.105263158

Average rotatable bonds  3.578947368

Number of hydrogen bond donors  26

Number of hydrogen bond acceptors  26

X logP energy  -0.8196

Hydropathy 



Literature Information


Title  Amino acid sequence of the Fv region of a human monoclonal IgM (protein WEA) with antibody activity against 3,4-pyruvylated galactose in Klebsiella polysaccharides K30 and K33.

DOI  10.1073/pnas.80.15.4837,

Publication Year  1983

PubMed ID  6410398,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.