SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB04185

Signal sequence   MEFGLSWVFLVAIIKGVQC

Length  19

Organism  Homo sapiens (Human)

UniProt ID  P01762,

Motif  1..19



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB04185.cif

Structure  SPKB04185.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2140.62954

Aliphatic index  133.1578947

Isoelectric point  6.231833229

Charge (pH=7)   -0.062510328

Topological polar surface area  729.55

Aromaticity  0.157894737

Average rotatable bonds  3.631578947

Number of hydrogen bond donors  26

Number of hydrogen bond acceptors  26

X logP energy  -1.2963

Hydropathy 



Literature Information


Title  The primary structure of a monoclonal IgA-immunoglobulin (IgA Tro.), II. The amino acid sequence of the H-chain, alpha-type, subgroup III; structure of the complete IgA-molecule (author's transl)

DOI  NA,

Publication Year  1975

PubMed ID  809331,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.