SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB04184

Signal sequence   MDWTWRVFCLLAVAPGAHS

Length  19

Organism  Homo sapiens (Human)

UniProt ID  P01743,

Motif  1..19



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  7A5R,

Predicted Structure ID  SPKB04184.cif

Structure  SPKB04184.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2160.53914

Aliphatic index  87.36842105

Isoelectric point  7.359696704

Charge (pH=7)   0.027361847

Topological polar surface area  778.25

Aromaticity  0.157894737

Average rotatable bonds  3.263157895

Number of hydrogen bond donors  29

Number of hydrogen bond acceptors  27

X logP energy  -3.82333

Hydropathy 



Literature Information


Title  Amino acid sequence of the variable region of heavy chain in immunoglobulin (Mot) having unusual papain cleavage sites.

DOI  10.1016/0161-5890(86)90039-8,

Publication Year  1986

PubMed ID  3084950,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.