SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB04183

Signal sequence   MAWIPLLLPLLILCTVSVAS

Length  20

Organism  Homo sapiens (Human)

UniProt ID  P01718,

Motif  1..20



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB04183.cif

Structure  SPKB04183.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2153.75274

Aliphatic index  195

Isoelectric point  5.922539791

Charge (pH=7)   -0.063990417

Topological polar surface area  675.12

Aromaticity  0.05

Average rotatable bonds  3.2

Number of hydrogen bond donors  24

Number of hydrogen bond acceptors  26

X logP energy  0.1148

Hydropathy 



Literature Information


Title  Structural rule of antibodies. Primary structure of a monoclonal immunoglobulin-L-chain of the lambda type, subgroup IV (Bence-Jones-protein Kern). V. The complete amino acid sequence and its genetic interpretation

DOI  NA,

Publication Year  1971

PubMed ID  5549568,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.