SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB04182

Signal sequence   MAWIPLLLPLLTLCTGSEA

Length  19

Organism  Homo sapiens (Human)

UniProt ID  P01717,

Motif  1..19



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB04182.cif

Structure  SPKB04182.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2042.52244

Aliphatic index  154.2105263

Isoelectric point  3.849962145

Charge (pH=7)   -1.062215294

Topological polar surface area  683.32

Aromaticity  0.052631579

Average rotatable bonds  3.210526316

Number of hydrogen bond donors  24

Number of hydrogen bond acceptors  26

X logP energy  -1.8434

Hydropathy 



Literature Information


Title  Amino acid sequence of the variable region of the light (lambda) chain from human myeloma cryoimmunoglobulin IgG Hil.

DOI  10.1021/bi00602a021,

Publication Year  1978

PubMed ID  418804,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.