SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB04179

Signal sequence   MAWSPLLLTLLAHCTGSWA

Length  19

Organism  Homo sapiens (Human)

UniProt ID  P01703,

Motif  1..19



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  7MU4,

Predicted Structure ID  SPKB04179.cif

Structure  SPKB04179.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2071.48274

Aliphatic index  118.4210526

Isoelectric point  7.35902981

Charge (pH=7)   0.026918674

Topological polar surface area  719.51

Aromaticity  0.105263158

Average rotatable bonds  3.157894737

Number of hydrogen bond donors  27

Number of hydrogen bond acceptors  27

X logP energy  -3.6046

Hydropathy 



Literature Information


Title  Amino acid sequence of the (lambda) light chain of a human myeloma immunoglobulin (IgG New).

DOI  10.1021/bi00703a037,

Publication Year  1974

PubMed ID  4814727,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.