SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB04178

Signal sequence   MEAPAQLLFLLLLWLPDTTG

Length  20

Organism  Homo sapiens (Human)

UniProt ID  P01624,

Motif  1..20



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  5MVZ,

Predicted Structure ID  SPKB04178.cif

Structure  SPKB04178.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2242.70134

Aliphatic index  146.5

Isoelectric point  3.550073557

Charge (pH=7)   -1.999794094

Topological polar surface area  772.58

Aromaticity  0.1

Average rotatable bonds  3.4

Number of hydrogen bond donors  25

Number of hydrogen bond acceptors  27

X logP energy  -1.2978

Hydropathy 



Literature Information


Title  The amino acid sequence of the variable regions of the light chains from two idiotypically cross reactive IgM anti-gamma globulins.

DOI  NA,

Publication Year  1976

PubMed ID  60899,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.