SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB04175

Signal sequence   MDMRVPAQLLGLLLLWFPGARC

Length  22

Organism  Homo sapiens (Human)

UniProt ID  P01599,

Motif  1..22



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB04175.cif

Structure  SPKB04175.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2501.10714

Aliphatic index  128.6363636

Isoelectric point  8.54983383

Charge (pH=7)   0.936449445

Topological polar surface area  876.82

Aromaticity  0.090909091

Average rotatable bonds  3.545454545

Number of hydrogen bond donors  31

Number of hydrogen bond acceptors  30

X logP energy  -2.50386

Hydropathy 



Literature Information


Title  The primary structure of a monoclonal IgM-immunoglobulin (macroglobulin Gal.), I. The amino acid sequence of the L-chain of kappa-type, subgroup I (author's transl)

DOI  NA,

Publication Year  1973

PubMed ID  4215718,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.