SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB04104

Signal sequence   MASRRLLLLCLAGLVLVTEA

Length  20

Organism  Sorex araneus (Eurasian common shrew) (European shrew)

UniProt ID  O46654,

Motif  1..20



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB04104.cif

Structure  SPKB04104.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2142.68974

Aliphatic index  180.5

Isoelectric point  8.549845238

Charge (pH=7)   0.937778084

Topological polar surface area  817.78

Aromaticity  0

Average rotatable bonds  3.6

Number of hydrogen bond donors  31

Number of hydrogen bond acceptors  28

X logP energy  -4.61736

Hydropathy 



Literature Information


Title  The evolution of the thyroid hormone distributor protein transthyretin in the order insectivora, class mammalia.

DOI  10.1093/oxfordjournals.molbev.a026403,

Publication Year  2000

PubMed ID  10908640,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.