SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB04078

Signal sequence   MEIKYLLTVFLVLLIVSDHCQA

Length  22

Organism  Androctonus amoreuxi (African fattail scorpion) (Scorpio amoreuxi)

UniProt ID  G8YYA6,

Motif  1..22



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB04078.cif

Structure  SPKB04078.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2549.12494

Aliphatic index  168.1818182

Isoelectric point  5.451763262

Charge (pH=7)   -0.972005167

Topological polar surface area  907.5

Aromaticity  0.090909091

Average rotatable bonds  3.818181818

Number of hydrogen bond donors  32

Number of hydrogen bond acceptors  33

X logP energy  -2.1635

Hydropathy 



Literature Information


Title  Antimicrobial/cytolytic peptides from the venom of the North African scorpion, Androctonus amoreuxi: biochemical and functional characterization of natural peptides and a single site-substituted analog.

DOI  10.1016/j.peptides.2012.03.016,

Publication Year  2012

PubMed ID  22484288,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.