SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB04041

Signal sequence   MRTLWIVALLLVGVEG

Length  16

Organism  Agkistrodon piscivorus leucostoma (Western cottonmouth) (Acontias leucostoma)

UniProt ID  C0HKC2,

Motif  1..16



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB04041.cif

Structure  SPKB04041.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  1770.20654

Aliphatic index  182.5

Isoelectric point  6.410149741

Charge (pH=7)   -0.000243889

Topological polar surface area  635.04

Aromaticity  0.0625

Average rotatable bonds  3.5625

Number of hydrogen bond donors  23

Number of hydrogen bond acceptors  21

X logP energy  -0.86253

Hydropathy 



Literature Information


Title  Phospholipase A(2) in the venom of three cottonmouth snakes.

DOI  10.1016/j.toxicon.2017.06.010,

Publication Year  2017

PubMed ID  28633930,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.