SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB04025

Signal sequence   MALSLFTVGQFIFLFWTISITEA

Length  23

Organism  Pseudopleuronectes americanus (Winter flounder) (Pleuronectes americanus)

UniProt ID  B1P0S1,

Motif  1..23



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB04025.cif

Structure  SPKB04025.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2636.14384

Aliphatic index  123.0434783

Isoelectric point  3.849983241

Charge (pH=7)   -1.000240578

Topological polar surface area  900.85

Aromaticity  0.217391304

Average rotatable bonds  3.565217391

Number of hydrogen bond donors  32

Number of hydrogen bond acceptors  32

X logP energy  -2.6271

Hydropathy 



Literature Information


Title  Hyperactive antifreeze protein from winter flounder is a very long rod-like dimer of alpha-helices.

DOI  10.1074/jbc.M500622200,

Publication Year  2005

PubMed ID  15716269,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.