SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB04021

Signal sequence   MAALHWLLLAALLGCTLA

Length  18

Organism  Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm)

UniProt ID  B0FHH8,

Motif  1..18



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB04021.cif

Structure  SPKB04021.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  1881.36774

Aliphatic index  179.4444444

Isoelectric point  7.35902981

Charge (pH=7)   0.026918674

Topological polar surface area  622.72

Aromaticity  0.055555556

Average rotatable bonds  3.222222222

Number of hydrogen bond donors  23

Number of hydrogen bond acceptors  23

X logP energy  -0.553

Hydropathy 



Literature Information


Title  A novel ML protein from Manduca sexta may function as a key accessory protein for lipopolysaccharide signaling.

DOI  10.1016/j.molimm.2008.02.006,

Publication Year  2008

PubMed ID  18343500,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.