SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB04008

Signal sequence   MLSTMQTVGAILMLSIVFVAGTKR

Length  24

Organism  Conus marmoreus (Marble cone)

UniProt ID  A1BQQ5,

Motif  1..24



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB04008.cif

Structure  SPKB04008.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2568.18984

Aliphatic index  125.8333333

Isoelectric point  11.65177567

Charge (pH=7)   1.997685954

Topological polar surface area  964.78

Aromaticity  0.041666667

Average rotatable bonds  3.625

Number of hydrogen bond donors  35

Number of hydrogen bond acceptors  36

X logP energy  -7.66343

Hydropathy 



Literature Information


Title  A single gamma-carboxyglutamic acid residue in a novel cysteine-rich secretory protein without propeptide.

DOI  10.1021/bi061311a,

Publication Year  2006

PubMed ID  17042501,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.