SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03998

Signal sequence   MGPMKVLLVLLVVMVAAPHIADA

Length  23

Organism  Paralithodes camtschaticus (Red king crab) (Maja camtschatica)

UniProt ID  A0A2I8B346,

Motif  1..23



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB03998.cif

Structure  SPKB03998.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2389.05734

Aliphatic index  165.2173913

Isoelectric point  7.549350682

Charge (pH=7)   0.089044841

Topological polar surface area  777.94

Aromaticity  0

Average rotatable bonds  3.260869565

Number of hydrogen bond donors  25

Number of hydrogen bond acceptors  30

X logP energy  -0.8734

Hydropathy 



Literature Information


Title  Paralithocins, Antimicrobial Peptides with Unusual Disulfide Connectivity from the Red King Crab, Paralithodes camtschaticus.

DOI  10.1021/acs.jnatprod.7b00780,

Publication Year  2018

PubMed ID  29338238,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.