SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03981

Signal sequence   MKTLLLTLVVVTIVCLDLGNS

Length  21

Organism  Micrurus fulvius (Eastern coral snake) (Coluber fulvius)

UniProt ID  U3FAE1,

Motif  1..21



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB03981.cif

Structure  SPKB03981.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2245.80474

Aliphatic index  185.2380952

Isoelectric point  6.160569088

Charge (pH=7)   -0.063838966

Topological polar surface area  832.65

Aromaticity  0

Average rotatable bonds  3.571428571

Number of hydrogen bond donors  30

Number of hydrogen bond acceptors  31

X logP energy  -5.0309

Hydropathy 



Literature Information


Title  Fulditoxin, representing a new class of dimeric snake toxins, defines novel pharmacology at nicotinic ACh receptors.

DOI  10.1111/bph.14954,

Publication Year  2020

PubMed ID  31877243,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.