SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03970

Signal sequence   MAPRTLWSCYLCCLLTAAAGA

Length  21

Organism  Homo sapiens (Human)

UniProt ID  Q9Y6C2,

Motif  1..21



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB03970.cif

Structure  SPKB03970.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2215.68954

Aliphatic index  98.0952381

Isoelectric point  8.041747906

Charge (pH=7)   0.811206426

Topological polar surface area  795.14

Aromaticity  0.095238095

Average rotatable bonds  3.095238095

Number of hydrogen bond donors  32

Number of hydrogen bond acceptors  31

X logP energy  -6.25223

Hydropathy 



Literature Information


Title  Diagnostic Exome Sequencing Identifies a Novel Gene, EMILIN1, Associated with Autosomal-Dominant Hereditary Connective Tissue Disease.

DOI  10.1002/humu.22920,

Publication Year  2016

PubMed ID  26462740,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.