SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03912

Signal sequence   MKPYFSCVFVFCFLIKLLTG

Length  20

Organism  Rattus norvegicus (Rat)

UniProt ID  Q9R1T7,

Motif  1..20



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB03912.cif

Structure  SPKB03912.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2356.97074

Aliphatic index  107

Isoelectric point  8.792490744

Charge (pH=7)   1.872594386

Topological polar surface area  720.16

Aromaticity  0.25

Average rotatable bonds  3.65

Number of hydrogen bond donors  27

Number of hydrogen bond acceptors  29

X logP energy  0.4064

Hydropathy 



Literature Information


Title  Identification and characterization of rat AILIM/ICOS, a novel T-cell costimulatory molecule, related to the CD28/CTLA4 family.

DOI  10.1006/bbrc.2000.3466,

Publication Year  2000

PubMed ID  11006126,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.