SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03886

Signal sequence   MAAALWGFFPVLLLLLLSGDVQS

Length  23

Organism  Homo sapiens (Human)

UniProt ID  Q9NPA0,

Motif  1..23



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  6WW7,

Predicted Structure ID  SPKB03886.cif

Structure  SPKB03886.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2461.98784

Aliphatic index  156.9565217

Isoelectric point  3.749987361

Charge (pH=7)   -1.001569216

Topological polar surface area  831.37

Aromaticity  0.130434783

Average rotatable bonds  3.304347826

Number of hydrogen bond donors  28

Number of hydrogen bond acceptors  29

X logP energy  -1.7854

Hydropathy 



Literature Information


Title  Structural basis for membrane insertion by the human ER membrane protein complex.

DOI  10.1126/science.abb5008,

Publication Year  2020

PubMed ID  32439656,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.