SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03878

Signal sequence   MKFETTKNKLHGNAYYQAQF

Length  20

Organism  Abrus precatorius (Indian licorice) (Glycine abrus)

UniProt ID  Q9M6E9,

Motif  1..20



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB03878.cif

Structure  SPKB03878.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2419.74004

Aliphatic index  29.5

Isoelectric point  9.867143282

Charge (pH=7)   2.088082583

Topological polar surface area  1013.54

Aromaticity  0.2

Average rotatable bonds  4.05

Number of hydrogen bond donors  34

Number of hydrogen bond acceptors  35

X logP energy  -9.2771

Hydropathy 



Literature Information


Title  Primary structure and function analysis of the Abrus precatorius agglutinin A chain by site-directed mutagenesis. Pro(199) Of amphiphilic alpha-helix H impairs protein synthesis inhibitory activity.

DOI  10.1074/jbc.275.3.1897,

Publication Year  2000

PubMed ID  10636890,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.