SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03856

Signal sequence   MGSLSNYALLQLTLTAFLTILVQPQH

Length  26

Organism  Homo sapiens (Human)

UniProt ID  Q9H9K5,

Motif  1..26



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB03856.cif

Structure  SPKB03856.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2873.40314

Aliphatic index  138.8461538

Isoelectric point  7.542349207

Charge (pH=7)   0.088042976

Topological polar surface area  1104.45

Aromaticity  0.076923077

Average rotatable bonds  3.538461538

Number of hydrogen bond donors  37

Number of hydrogen bond acceptors  39

X logP energy  -8.5707

Hydropathy 



Literature Information


Title  HEMO, an ancestral endogenous retroviral envelope protein shed in the blood of pregnant women and expressed in pluripotent stem cells and tumors.

DOI  10.1073/pnas.1702204114,

Publication Year  2017

PubMed ID  28739914,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.