SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03848

Signal sequence   MKFTTLLFLAAVAGALVYA

Length  19

Organism  Homo sapiens (Human)

UniProt ID  Q9GZZ8,

Motif  1..19



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB03848.cif

Structure  SPKB03848.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2000.47004

Aliphatic index  138.9473684

Isoelectric point  9.298300651

Charge (pH=7)   0.996838851

Topological polar surface area  673.83

Aromaticity  0.157894737

Average rotatable bonds  3.263157895

Number of hydrogen bond donors  24

Number of hydrogen bond acceptors  25

X logP energy  -1.5706

Hydropathy 



Literature Information


Title  Human Basal Tear Peptidome Characterization by CID, HCD, and ETD Followed by in Silico and in Vitro Analyses for Antimicrobial Peptide Identification.

DOI  10.1021/acs.jproteome.5b00179,

Publication Year  2015

PubMed ID  25946035,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.