SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03823

Signal sequence   MLPLLLGLLGPAACWA

Length  16

Organism  Homo sapiens (Human)

UniProt ID  Q9BXJ3,

Motif  1..16



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB03823.cif

Structure  SPKB03823.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  1639.08984

Aliphatic index  165

Isoelectric point  5.922539791

Charge (pH=7)   -0.063990417

Topological polar surface area  498.03

Aromaticity  0.0625

Average rotatable bonds  2.9375

Number of hydrogen bond donors  17

Number of hydrogen bond acceptors  19

X logP energy  0.6887

Hydropathy 



Literature Information


Title  Identification of C1qTNF-related protein 4 as a potential cytokine that stimulates the STAT3 and NF-KappaB pathways and promotes cell survival in human cancer cells.

DOI  10.1016/j.canlet.2011.05.005,

Publication Year  2011

PubMed ID  21658842,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.