SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03806

Signal sequence   MRRLLIPLALWLGAVGVGVA

Length  20

Organism  Homo sapiens (Human)

UniProt ID  Q99969,

Motif  1..20



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB03806.cif

Structure  SPKB03806.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2105.65904

Aliphatic index  175.5

Isoelectric point  12.50010931

Charge (pH=7)   1.997977677

Topological polar surface area  747.02

Aromaticity  0.05

Average rotatable bonds  3.3

Number of hydrogen bond donors  27

Number of hydrogen bond acceptors  24

X logP energy  -1.68216

Hydropathy 



Literature Information


Title  Characterization of human circulating TIG2 as a ligand for the orphan receptor ChemR23.

DOI  10.1016/s0014-5793(03)01312-7,

Publication Year  2003

PubMed ID  14675762,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.