SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03804

Signal sequence   MKLTFFLGLLALISCFTPSES

Length  21

Organism  Homo sapiens (Human)

UniProt ID  Q99935,

Motif  1..21



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB03804.cif

Structure  SPKB03804.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2318.81464

Aliphatic index  116.1904762

Isoelectric point  6.231833229

Charge (pH=7)   -0.062510328

Topological polar surface area  801

Aromaticity  0.142857143

Average rotatable bonds  3.523809524

Number of hydrogen bond donors  29

Number of hydrogen bond acceptors  31

X logP energy  -4.3283

Hydropathy 



Literature Information


Title  Human Opiorphin, a natural antinociceptive modulator of opioid-dependent pathways.

DOI  10.1073/pnas.0605865103,

Publication Year  2006

PubMed ID  17101991,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.