SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03782

Signal sequence   MKPSLLCRPLSCFLMLLPWPLATLT

Length  25

Organism  Homo sapiens (Human)

UniProt ID  Q969Z4,

Motif  1..25



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB03782.cif

Structure  SPKB03782.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2845.61684

Aliphatic index  128.8

Isoelectric point  8.828181491

Charge (pH=7)   1.873736522

Topological polar surface area  911.19

Aromaticity  0.08

Average rotatable bonds  3.4

Number of hydrogen bond donors  33

Number of hydrogen bond acceptors  36

X logP energy  -2.08203

Hydropathy 



Literature Information


Title  RELT, a new member of the tumor necrosis factor receptor superfamily, is selectively expressed in hematopoietic tissues and activates transcription factor NF-kappaB.

DOI  10.1182/blood.v97.9.2702,

Publication Year  2001

PubMed ID  11313261,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.