SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03780

Signal sequence   MAAAMPLALLVLLLLGPGGWC

Length  21

Organism  Homo sapiens (Human)

UniProt ID  Q969N2,

Motif  1..21



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  7WLD,

Predicted Structure ID  SPKB03780.cif

Structure  SPKB03780.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2110.70514

Aliphatic index  162.8571429

Isoelectric point  5.922539791

Charge (pH=7)   -0.063990417

Topological polar surface area  643.53

Aromaticity  0.047619048

Average rotatable bonds  3

Number of hydrogen bond donors  22

Number of hydrogen bond acceptors  25

X logP energy  0.2192

Hydropathy 



Literature Information


Title  PIG-S and PIG-T, essential for GPI anchor attachment to proteins, form a complex with GAA1 and GPI8.

DOI  10.1093/emboj/20.15.4088,

Publication Year  2001

PubMed ID  11483512,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.