SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03778

Signal sequence   MAAPSGGWNGVGASLWAALLLGAVALRPAEA

Length  31

Organism  Homo sapiens (Human)

UniProt ID  Q969H8,

Motif  1..31



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB03778.cif

Structure  SPKB03778.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2978.46174

Aliphatic index  110.6451613

Isoelectric point  6.410149741

Charge (pH=7)   -0.000243889

Topological polar surface area  1133.07

Aromaticity  0.064516129

Average rotatable bonds  2.870967742

Number of hydrogen bond donors  39

Number of hydrogen bond acceptors  38

X logP energy  -9.97753

Hydropathy 



Literature Information


Title  Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini.

DOI  10.1073/pnas.0908958106,

Publication Year  2009

PubMed ID  19892738,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.