SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03774

Signal sequence   MVKMQVIFIAFIAVIACSMVYG

Length  22

Organism  Olivierus martensii (Manchurian scorpion) (Mesobuthus martensii)

UniProt ID  Q95P90,

Motif  1..22



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB03774.cif

Structure  SPKB03774.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2435.10034

Aliphatic index  137.2727273

Isoelectric point  8.522939048

Charge (pH=7)   0.934864135

Topological polar surface area  783.99

Aromaticity  0.136363636

Average rotatable bonds  3.590909091

Number of hydrogen bond donors  28

Number of hydrogen bond acceptors  31

X logP energy  -0.9118

Hydropathy 



Literature Information


Title  Charaterization of bumarsin, a 3-hydroxy-3-methylglutaryl-coenzyme reductase inhibitor from Mesobuthus martensii Karsch venom.

DOI  10.1016/j.toxicon.2012.04.352,

Publication Year  2012

PubMed ID  22575281,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.