SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03762

Signal sequence   MAVTDSLSRAATVLATVLLLSFGSVAA

Length  27

Organism  Homo sapiens (Human)

UniProt ID  Q92643,

Motif  1..27



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  7W72,

Predicted Structure ID  SPKB03762.cif

Structure  SPKB03762.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2665.14074

Aliphatic index  137.4074074

Isoelectric point  6.338718596

Charge (pH=7)   -0.001572528

Topological polar surface area  1060.73

Aromaticity  0.037037037

Average rotatable bonds  3.148148148

Number of hydrogen bond donors  39

Number of hydrogen bond acceptors  38

X logP energy  -11.54623

Hydropathy 



Literature Information


Title  PIG-S and PIG-T, essential for GPI anchor attachment to proteins, form a complex with GAA1 and GPI8.

DOI  10.1093/emboj/20.15.4088,

Publication Year  2001

PubMed ID  11483512,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.