General Information
SPKB ID SPKB03736
Signal sequence MGPQRRLSPAGAALLWGFLLQLTAA
Length 25
Organism Homo sapiens (Human)
UniProt ID Q8TCT8,
Motif 1..25
Activity Information
Pathway SRP-dependent
Natural/Artificial Natural
Subcellular location ER
Secretion efficiency NA
Type Sec/SPI
Structure Information
PDB ID NA,
Predicted Structure ID SPKB03736.cif
Physicochemical Information
Molecular weight 2639.15684
Aliphatic index 113.6
Isoelectric point 12.50010931
Charge (pH=7) 1.997977677
Topological polar surface area 1010.37
Aromaticity 0.08
Average rotatable bonds 3.28
Number of hydrogen bond donors 35
Number of hydrogen bond acceptors 33
X logP energy -7.53336
Hydropathy 
Literature Information
Title Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins.
Publication Year 2004
PubMed ID 15385547,
Patent ID NA,
