General Information
SPKB ID SPKB03735
Signal sequence MAAAVAAALARLLAAFLLLAAQVAC
Length 25
Organism Homo sapiens (Human)
UniProt ID Q8TCT7,
Motif 1..25
Activity Information
Pathway SRP-dependent
Natural/Artificial Natural
Subcellular location ER
Secretion efficiency NA
Type Sec/SPI
Structure Information
PDB ID NA,
Predicted Structure ID SPKB03735.cif
Physicochemical Information
Molecular weight 2414.00864
Aliphatic index 164.8
Isoelectric point 8.549912035
Charge (pH=7) 0.936006272
Topological polar surface area 866.71
Aromaticity 0.04
Average rotatable bonds 3.04
Number of hydrogen bond donors 31
Number of hydrogen bond acceptors 30
X logP energy -4.68473
Hydropathy 
Literature Information
Title Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins.
Publication Year 2004
PubMed ID 15385547,
Patent ID NA,
